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When is it contraindicated to use Ibuprofen?

  1. Active vomiting

  2. Use within 4 hours

  3. Known liver disease

  4. CVA or TBI in last 24 hrs

The correct answer is: Active vomiting

The use of Ibuprofen is contraindicated in cases of active vomiting primarily because it indicates a potential for gastrointestinal bleeding or irritation. Administering Ibuprofen during active vomiting can further exacerbate these issues, as the medication can irritate the stomach lining and increase the risk of complications. In such cases, the risk of worsening the patient's condition is significant, as both the gastrointestinal tract and the symptoms of vomiting could become more problematic. In addition, while other options like the use of Ibuprofen within four hours or known liver disease can pose risks, they don't represent an immediate and acute contraindication like active vomiting does. The scenario of CVA or TBI in the last 24 hours suggests caution due to the possibility of increased bleeding risk, but it does not provide the same urgent concern regarding active gastrointestinal issues that may arise from concurrent vomiting. Thus, the immediate risks associated with active vomiting highlight a clear contraindication for the use of Ibuprofen in this situation.