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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever. However, its use comes with certain contraindications to avoid exacerbating existing conditions.

In the case of active vomiting, the use of ibuprofen is contraindicated for several reasons. First, active vomiting can increase the risk of gastrointestinal bleeding, which is one of the potential side effects of NSAIDs like ibuprofen. Second, when a patient is already experiencing vomiting, it may indicate an underlying condition that is aggravated by NSAIDs. Administering ibuprofen during this condition may lead to further complications, particularly regarding fluid balance and the ability to retain medications effectively.

This situation necessitates a more cautious approach, as medications given orally may not be adequately absorbed, and their intended therapeutic effects could be compromised. For these reasons, active vomiting is a clear contraindication for the use of ibuprofen.

Other listed conditions may have considerations for ibuprofen use but do not present the immediate risk that active vomiting does. For example, using ibuprofen within a short time frame may be acceptable in some cases, known liver disease does raise concerns but would depend on severity, and prior cerebrovascular accident (CVA) or traumatic brain